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Clinical history
33-year-old with high-risk HPV positive screening result.
Specimen
Colposcopic punch biopsy · Stain: H&E and p16
Microscopic description
Full-thickness loss of maturation with nuclear crowding, hyperchromasia and mitoses above the basal third. Block-positive p16.
Diagnostic question
How does p16 immunohistochemistry assist in classification?
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