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Clinical history
3-year-old with an abdominal mass.
Specimen
Radical nephrectomy · Stain: H&E
Microscopic description
Triphasic tumour with blastemal, epithelial and stromal components. No nuclear anaplasia identified in sections examined.
Diagnostic question
Why is anaplasia assessment critical in this tumour?
Reveal differential diagnosis
Clear cell sarcoma of kidney
Rhabdoid tumour
Congenital mesoblastic nephroma
Reveal final diagnosis
Nephroblastoma, triphasic, no anaplasia identified
Learning points
Anaplasia determines risk stratification
Assess capsular and sinus invasion
Note prior chemotherapy effect where applicable
Self-assessment
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